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Accueil du site > Jobs - PostDoc - These > Stage M2 au sein de la Danish Cancer Society (Copenhague, Danemark).

Stage M2 au sein de la Danish Cancer Society (Copenhague, Danemark).

par Nord & Ile de France - 1er mars

Deciphering redox regulation mechanisms of protein kinases by nitric oxide and their implication in cancer development and progression

The Computational Biology Laboratory is searching for a highly motivated master student to perform an internship in computational biochemistry within the Danish Cancer Society Research Center (Copenhagen, Denmark) starting late spring or after summer, the duration being flexible.

The student will use molecular modeling methods to investigate the impact of the S-nitrosylation post-translational modification on cancer-related proteins structure. She/he will run all-atom molecular dynamics simulations and in-depth structural analysis with state-of-the-art techniques to understand how S-nitrosylation regulates the activity of kinase proteins. The latter are of strong biological relevance for they are known to be over-expressed in cancer cells. As a consequence, they constitute important molecular targets for the development of anticancer drugs. It is thus crucial to understand the mechanisms underlying their regulation to be able to design new effective targeted treatment strategies.

The Computational Biology Laboratory offers a stimulating, high-level, and friendly working environment, in which the student will have the possibility to acquire strong skills in molecular modeling and cancer biology and work in collaboration with an experimental group at the institute and other groups in UK.

A person with a background on chemistry/biochemistry could be the best match for this project, but also with a more biophysics oriented angle attracted by complex biological systems.Knowledge about molecular dynamics simulations and Linux would be a strong advantage.

Important : The student should have his/her own travel fellowship (eg Erasmus).

Everyone is very welcome to contact us. Come and join the crew !

Our group : https://sites.google.com/site/cblca...

Contact : Emmanuelle Bignon (embi@cancer.dk) and Elena Papaleo (elenap@cancer.dk)